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00925njm 22002777a 4500 dc Lagunas García, Luisa Natalia author Calmarza-Font, Isabel author Diz-Chaves, Yolanda author Garcia-Segura, Luis author 2010 Ovarian hormones exert anti-depressive and anxiolytic actions. In this study we have analyzed the effects of ovariectomy on the development of anxiety and depression-like behaviors and on cell proliferation in the hippocampus of mice submitted to chronic unpredictable stress. Animals submitted to stress 4 months after ovariectomy showed a significant increase in immobility behavior in the forced swimming test compared to animals submitted to stress 2 weeks after ovariectomy. In addition, long-term ovariectomy resulted in a significant decrease on the time spent in the open arms in the elevated plus-maze test compared to control animals. Stress did not significantly affect cell proliferation in the hilus of the dentate gyrus. However, ovariectomy resulted in a significant decrease in cell proliferation. These results indicate that long-term deprivation of ovarian hormones enhances the effect of chronic unpredictable stress on depressive- and anxiety-like behaviors in mice. Therefore, a prolonged deprivation of ovarian hormones may represent a risk factor for the development of depressive and anxiety symptoms after the exposure to stressful experiences. Lagunas N, Calmarza-Font I, Diz-Chaves Y, Garcia-Segura LM. Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress. Horm Behav. 2010 Nov;58(5):786-91. doi: 10.1016/j.yhbeh.2010.07.014. Epub 2010 Aug 5. PMID: 20691693. 0018-506X 10.1016/j.yhbeh.2010.07.014 https://hdl.handle.net/20.500.14352/95489 https://www.doi.org/10.1016/j.yhbeh.2010.07.014 https://www.sciencedirect.com/science/article/pii/S0018506X10002102?via%3Dihub Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress