2026-06-28T10:09:04Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/954992025-03-18T13:06:04Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Durán Sampedro, Gonzalo
author
Xue, Evelyn .
author
Evelynoreno-Simoni, Evelyn
author
Paramio, Celia
author
Torres, Tomás
author
Ng, Dennis K. P.
author
Torre, Gema de la
2024-01-25T14:45:15Z
2024-01-25T14:45:15Z
2023
Durán-Sampedro, Gonzalo, et al. «Glycosylated BODIPY- Incorporated Pt(II) Metallacycles for Targeted and Synergistic Chemo-Photodynamic Therapy». Journal of Medicinal Chemistry, vol. 66, n.o 5, marzo de 2023, pp. 3448-59. https://doi.org/10.1021/acs.jmedchem.2c01940.
0022-2623
10.1021/acs.jmedchem.2c01940
https://hdl.handle.net/20.500.14352/95499
1520-4804
https://doi.org/10.1021/acs.jmedchem.2c01940
Pt(II)-BODIPY complexes combine the chemotherapeutic activity of Pt(II) with the photocytotoxicity of BODIPYs. Additional conjugation with targeting ligands can boost the uptake by cancer cells that overexpress the corresponding receptors. We describe two Pt(II) triangles, 1 and 2, built with pyridyl BODIPYs functionalized with glucose (3) or triethylene glycol methyl ether (4), respectively. Both 1 and 2 showed higher singlet oxygen quantum yields than 3 and 4, due to the enhanced singlet-to -triplet intersystem crossing. To evaluate the targeting effect of the glycosylated derivative, in vitro experiments were performed using glucose transporter 1 (GLUT1)-positive HT29 and A549 cancer cells, and noncancerous HEK293 cells as control. Both 1 and 2 showed higher cellular uptake than 3 and 4. Specifically, 1 was selective and highly cytotoxic toward HT29 and A549 cells. The synergistic chemo-and photodynamic behavior of the metallacycles was also confirmed. Notably, 1 exhibited superior efficacy toward the cisplatin-resistant R-HepG2 cells. Enhance Cellular Uptake Chemotherapeutic Activity Photoeeneltlaen for PDT
eng
Glycosylated BODIPY- Incorporated Pt(II) Metallacycles for Targeted and Synergistic Chemo-Photodynamic Therapy
journal article
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Chemo-Photodynamic_Therapy.pdf
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https://docta.ucm.es/bitstreams/ef2caa9e-4468-4564-8b57-a5da07b7db5a/download
File
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Chemo-Photodynamic_Therapy.pdf.txt