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oai:docta.ucm.es:20.500.14352/957752025-03-18T15:23:44Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Barrio, Manuel de author Tornero Molina, Pilar author Prieto, A. author Sainza, T. author Zubeldia Ortuño, José Manuel author Herrero, T. author 1997-05-01 Citiolone (N-acetylhomocysteinethiolactone) is a thiolic­derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolytic drugs have rarely been implicated in the fixed drug eruption etiology. We report on a patient who presented several episodes of fixed exanthema related to citiolone intake. The patch test with citiolone (10% in dimethyl sulfoxide) was negative. The diagnosis was confirmed by a positive controlled oral challenge test. Other mucolytic thiolic­derivatives (N-acetylcysteine) were tolerated by the patient, thus crossreactivity between these drugs seems to be unlikely. de Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia JM, Herrero T. Recurrent fixed drug eruption caused by citiolone. J Investig Allergol Clin Immunol. 1997 May-Jun;7(3):193-4. PMID: 9252880. 1018-9068 https://hdl.handle.net/20.500.14352/95775 1698-0808 9252880 https://pubmed.ncbi.nlm.nih.gov/9252880/ Recurrent fixed drug eruption caused by citiolone