2026-06-29T07:44:13Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/957782025-05-10T00:09:06Zcom_20.500.14352_14col_20.500.14352_15
Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics
Inglés
Revuelta, Julia
Fuentes, Roberto
Lagartera, Laura
Hernáiz Gómez-Degano, María Josefa
Bastida, Agatha
García-Junceda, Eduardo
Fernández-Mayoralas, Alfonso
Fernández-Mayoralas, Alfonso
Chemical Synthesis, Design, Glycosaminoglycans
Ciencias
23 Química
A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.
Ministerio de Economía y Competitividad (España)
Depto. de Química en Ciencias Farmacéuticas
Fac. de Farmacia
TRUE
pub
2024-01-29T09:23:01Z
2024-01-29T09:23:01Z
2018
journal article
VoR
https://hdl.handle.net/20.500.14352/95778
1359-7345
10.1039/c8cc08067d
1364-548X
eng
info:eu-repo/grantAgreement/MAT2015-65184-C2-2-R
info:eu-repo/grantAgreement/CTQ2015-66206-C2-1-R
Revuelta J, Fuentes R, Lagartera L, Hernáiz MJ, Bastida A, García-Junceda E, et al. Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics. Chem Commun 2018;54:13455–8. https://doi.org/10.1039/C8CC08067D.
restricted access
application/pdf
Royal Society of Chemistry