2026-06-29T07:22:28Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/957972025-07-12T00:20:43Zcom_20.500.14352_14col_20.500.14352_15
Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography
Moraga Yébenes, Ana
Gómez Vallejo, Vanessa
Cuartero Desviat, María Isabel
Szczupak, Boguslaw
San Sebastián, Eneko
Markuerkiaga, Irati
Pradillo Justo, Jesús Miguel
Higuchi, Makoto
Llop, Jordi
Moro Sánchez, María Ángeles
Martín, Abraham
Lizasoaín Hernández, Ignacio
615.01/.03
3′-deoxy-3′-[18F]fluorothymidine
Positron emission tomography
T2W-MRI
[11C]PK11195
Cerebral ischemia
Magnetic resonance imaging
Middle cerebral artery occlusion
Toll-like receptor 4
Ciencias Biomédicas
32 Ciencias Médicas
The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4(+/+)and TLR4(-/-)mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4(-/-)mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.
Depto. de Farmacología y Toxicología
Fac. de Medicina
TRUE
pub
2024-01-29T09:45:19Z
2024-01-29T09:45:19Z
2016
journal article
VoR
https://hdl.handle.net/20.500.14352/95797
0271-678X
10.1177/0271678x15627657
1559-7016
eng
Moraga A, Gómez-Vallejo V, Cuartero MI, Szczupak B, San Sebastián E, Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MÁ, Martín A, Lizasoain I. Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography. J Cereb Blood Flow Metab. 2016 Apr;36(4):702-8. doi: 10.1177/0271678X15627657
restricted access
application/pdf
SAGE Publications