2026-06-28T20:31:57Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/958432025-04-01T00:08:39Zcom_20.500.14352_14col_20.500.14352_15

Phosphorogenic dipyrrinato-iridium(III) complexes as photosensitizers for photodynamic therapy Prieto Castañeda, Alejandro Lérida Viso, Araceli Avellanal Zaballa, Edurne Sola Llano, Rebeca Bañuelos, Jorge Rodríguez Agarrabeitia, Antonia Martínez Mañez, Ramon Ortiz García, María Josefa We have designed and synthesized a family of Ir(III) metal complexes coordinated with two cyclometalated bisfluorophenylpyridine ligands and an ancillary dipyrromethene which is functionalized with a mesityl group (Ir(dipy)-1), an α-chloroacetyl ester (Ir(dipy)-2) or a chain containing an ammonium cation (Ir(dipy)-3). The Ir (III) complexes feature a high triplet state population enabling red phosphorescence and efficient singlet oxygen generation. Ir(dipy)-2 and Ir(dipy)-3 are demonstrated to stain cells in both one-photon and two-photon confocal imaging. Moreover, Ir(dipy)-2 and Ir(dipy)-3 produce ROS in cells upon irradiation, inducing cell death by apoptosis. Colocalization studies in SK-Mel-103 cells show that Ir(dipy)-3 is partially accumulated in mitochondria and induces upon irradiation a disruption in their morphology. Overall our studies demonstrate that the prepared Ir(III) act as photosensitizers able to kill cells under irradiation, being suitable candidates for photodynamic therapy applications. 2024-01-29T10:31:46Z 2024-01-29T10:31:46Z 2024-01-29T10:31:46Z 2021 journal article https://hdl.handle.net/20.500.14352/95843 0143-7208 10.1016/j.dyepig.2021.109886 1873-3743 eng MAT2017-83856-C3-2-P and 3-P PID2020-11455 GB-C32 and C33 IT912-16 Prieto-Castañeda, A.; Lérida-Viso, A.; Avellanal-Zaballa, E.; Sola-Llano, R.; Bañuelos, J.; Agarrabeitia, A.R.; Martínez-Mañez, R.; Ortiz, M.J., Dyes Pigment. 2022, 197, 10988602 restricted access Elsevier