2026-06-08T02:44:04Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/962792025-03-18T13:24:35Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Villalba Orero, María author López-Olañeta, Marina author García-Pavía, Pablo author Lara-Pezzi, Enrique 2024-01-30T06:44:06Z 2024-01-30T06:44:06Z 2017 Villalba-Orero, M., López-Olañeta, M., García-Pavía, P., & Lara-Pezzi, E. (2017). Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models. Journal of cardiovascular translational research, 10(5-6), 499–501. https://doi.org/10.1007/s12265-017-9765-x 1937-5387 10.1007/s12265-017-9765-x https://hdl.handle.net/20.500.14352/96279 1937-5395 https://doi.org/10.1007/s12265-017-9765-x 28812262 Heart failure (HF) is a major cause of death and hospitalization worldwide. Despite advances in reducing mortality, prognosis remains poor and prevalence has reached epidemic proportions. The limitations of available preclinical models represent a major hurdle in the development of new therapies. Myocardial infarction (MI) is a main cause of HF in humans, and mouse models of MI are often used to study HF mechanisms and experimental treatments. We investigated whether MI in mice constitutes an appropriate model of HF. Permanent ligation of the left coronary artery induced severe and persistent systolic dysfunction and ventricular dilatation. Mouse follow-up for 10 months showed no significant evidence of lung congestion or other pulmonary defects associated with HF. No difference was observed in the capacity of infarcted mice to exercise compared to control animals. These results indicate that severe cardiac dysfunction in mice is not sufficient to demonstrate the presence of HF eng Attribution-NonCommercial-NoDerivatives 4.0 International Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models journal article 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