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Current Development of Molecular Coronary Plaque Imaging using Magnetic Resonance Imaging towards Clinical Application Lavín Plaza, Begoña Phinikaridou, Alkystis Henningsson, Markus Botnar, René 577.1 Molecular MR imaging Atherosclerosis Coronary artery disease Bioquímica (Química) 24 Ciencias de la Vida Cardiovascular disease (CVD) remains the leading cause of death in Western countries despite improvements in prevention, diagnosis and treatment. Atherosclerosis is a chronic inflammatory disease that remains clinically silent for many decades. Sudden rupture of “high-risk/vulnerable” plaques has been shown to be responsible for the majority of acute cardiovascular events, including myocardial infarction and stroke. Therefore, early detection of biological processes associated with atherosclerosis progression and plaque instability may improve diagnosis and treatment and help to better monitor the effectiveness of therapeutic interventions. Molecular magnetic resonance imaging (MRI) is a promising tool to detect molecular and cellular changes in the carotid, aortic and coronary vessel wall including endothelial dysfunction, inflammation, vascular remodelling, enzymatic activity, intraplaque haemorrhage and fibrin deposition and thus may allow early detection of unstable lesions and improve the prediction of future coronary events. Evaluation of atherosclerosis at both, the preclinical and clinical level includes non-contrast-enhanced (NCE) and contrast-enhanced (CE) MRI with and without the use of MR contrast agents. To increase the biological information obtained by MRI a variety of targeted-specific molecular probes have been developed for the non-invasive visualization of particular biological processes at the molecular and cellular level. This review will discuss the recent advances in molecular MRI of atherosclerosis, covering both pulse sequence development and also the design of novel contrast agents, for imaging atherosclerotic disease in vivo. Depto. de Bioquímica y Biología Molecular Fac. de Ciencias Químicas TRUE pub 2024-01-30T12:27:56Z 2024-01-30T12:27:56Z 2014 journal article VoR https://hdl.handle.net/20.500.14352/96481 1941-9066 10.1007/s12410-014-9309-6 1941-9074 eng Lavin, B., Phinikaridou, A., Henningsson, M. et al. Current Development of Molecular Coronary Plaque Imaging using Magnetic Resonance Imaging towards Clinical Application. Curr Cardiovasc Imaging Rep 7, 9309 (2014). https://doi.org/10.1007/s12410-014-9309-6 restricted access application/pdf Springer