2026-06-27T16:26:08Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/965762025-02-22T00:49:06Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Quintero Gutiérrez Del Álamo, Francisco Javier
author
López Muñoz, Francisco
author
Alamo, Cecilio
author
Loro, Mercedes
author
García Campos, Natalia
2024-01-30T13:32:12Z
2024-01-30T13:32:12Z
2009
uintero J, López-Muñoz F, Alamo C, Loro M, García-Campos N. Reboxetine for ADHD in children non-responders or with poor tolerance to methylphenidate: a prospective long-term open-label study. Atten Defic Hyperact Disord. 2010 Nov;2(3):107-13. doi: 10.1007/s12402-010-0027-x. Epub 2010 May 25. PMID: 21432596
1866-6116
10.1007/s12402-010-0027-x
https://hdl.handle.net/20.500.14352/96576
https://doi.org/10.1007/s12402-010-0027-x
https://www.webofscience.com/wos/woscc/full-record/WOS:000214414900002
Up to 30% of patients with attention-deficit hyperactivity disorder (ADHD) treated with psychostimulants discontinue the treatment because of intolerance or lack of therapeutic response. Therapeutic alternatives are needed for such patients. In the present case series, we study the effectiveness of reboxetine over a period of 6 months in a sample of 14 children diagnosed with ADHD according to DSM-IV-TR criteria, who had responded only partially or had presented poor tolerance to conventional treatment with methylphenidate. Clinical efficacy was evaluated through the application of the 18-item Attention-Deficit Hyperactivity Disorder Rating Scale (ADHD-RS-IV) and the Clinical Global Impressions-Global Improvement Scale (CGI-I). Percentages of responders (ADHD-RS ≥ 25%) and improvers (CGI-I absolute value < 4) were 90.9 and 72.7%, respectively. No serious side-effects were observed during treatment, the most frequent effects being headaches and insomnia. The initial findings of our study show that reboxetine may constitute an effective tool for long-term treatment of children with ADHD who present poor response or poor tolerance to initial treatment with methylphenidate.
eng
Reboxetine for ADHD in children non-responders or with poor tolerance to methylphenidate: a prospective long-term open-label study
journal article
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URL
https://docta.ucm.es/bitstreams/bd1e1fc9-04f4-4256-8c0c-9e014609807a/download
File
MD5
24bf30f4da756dee4d5e07968320fcac
239427
application/pdf
Reboxetine_for_ADHD_in_children.pdf