2026-06-08T03:45:55Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/967102025-03-18T12:04:05Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Vilela García, Diana author Cossío, Unai author Parmar, Jemish author Martínez-Villacorta, Angel author Gómez-Vallejo, Vanessa author Llop, Jordi author Sánchez, Samuel 2024-01-30T17:03:13Z 2024-01-30T17:03:13Z 2018 Diana Vilela, Unai Cossío, Jemish Parmar, Angel M. Martínez-Villacorta, Vanessa Gómez-Vallejo, Jordi Llop, and Samuel Sánchez ACS Nano 2018 12 (2), 1220-1227 DOI: 10.1021/acsnano.7b07220 1936-0851 10.1021/acsnano.7b07220 https://hdl.handle.net/20.500.14352/96710 1936-086X https://doi.org/10.1021/acsnano.7b07220 Micro/nanomotors are useful tools for several biomedical applications, including targeted drug delivery and minimally invasive microsurgeries. However, major challenges such as in vivo imaging need to be addressed before they can be safely applied on a living body. Here, we show that positron emission tomography (PET), a molecular imaging technique widely used in medical imaging, can also be used to track a large population of tubular Au/PEDOT/Pt micromotors. Chemisorption of an iodine isotope onto the micromotor’s Au surface rendered them detectable by PET, and we could track their movements in a tubular phantom over time frames of up to 15 min. In a second set of experiments, micromotors and the bubbles released during self-propulsion were optically tracked by video imaging and bright-field microscopy. The results from direct optical tracking agreed with those from PET tracking, demonstrating that PET is a suitable technique for the imaging of large populations of active micromotors in opaque environments, thus opening opportunities for the use of this mature imaging technology for the in vivo localization of artificial swimmers. eng Attribution-NonCommercial-NoDerivatives 4.0 International Medical Imaging for the Tracking of Micromotors journal article 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