2026-08-20T06:03:51Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/967452024-02-14T01:09:23Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Güemes, Itziar
author
Rodríguez, Alberto
author
Mac-Dowell Mata, Karina Soledad
author
Díaz Marsa, Marina Francisca
author
Leza Cerro, Juan Carlos
author
Carrasco Perera, José Luis
2024-01-30T18:03:25Z
2024-01-30T18:03:25Z
2013-08
MacDowell KS, Díaz-Marsá M, Güemes I, Rodríguez A, Leza JC, Carrasco JL. Inflammatory activation and cholinergic anti-inflammatory system in eating disorders. Brain Behav Immun. 2013 Aug;32:33-9. doi: 10.1016/j.bbi.2013.04.006. PMID: 23624297.
0889-1591
10.1016/j.bbi.2013.04.006
https://hdl.handle.net/20.500.14352/96745
https://www.sciencedirect.com/science/article/pii/S0889159113001748
https://pubmed.ncbi.nlm.nih.gov/23624297/
Dysfunctional serotoninergic regulation and hypothalamic-pituitary-adrenal (HPA) axis overreactivity have been consistently reported in research studies with eating disorders (ED). In addition, the links between stress response, serotonin function, HPA axis and inflammatory mechanisms in ED have also been suggested in a number of studies. In our study, inflammatory parameters in white blood cells were investigated in 26 female patients with ED and 25 healthy control subjects matched for sex, age and ethnicity. Patients were free of medication for at least two weeks at the time of the study. Results showed a significant increase in plasma levels of the proinflammatory cytokine IL1β and the protein expression of cyclooxygenase 2 (COX2) in peripheral mononuclear blood cells (PMBCs) in ED patients compared with controls. As well as a significant increase of the oxidative-nitrosative marker TBARS (Thiobarbituric Acid Reactive Substances) in plasma. These findings were associated with increased expression of the alpha7 subunit of the nicotinic receptor (α7nAChR) in PMBC in ED patients independent of plasma cotinine levels. These results suggest that a pro-inflammatory and oxidant phenotype might be present in ED patients. Further research on cellular inflammatory and anti-inflammatory pathways might be oriented to investigate differences between ED subtypes and to search for new potential targets for pharmacological treatment.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Inflammatory activation and cholinergic anti-inflammatory system in eating disorders
journal article
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https://docta.ucm.es/bitstreams/dcc1c560-e531-4772-a97f-eaf7b71a5e0c/download
File
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ce08a3ecad1ec11f7701b0cd9e2fb547
589262
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PMID 23624297.pdf