2026-06-27T22:48:02Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/968222025-03-18T12:29:36Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Brackhan, Mirjam author Arribas Blázquez, Marina author Lastres-Becker, Isabel author 2023-08-04 Although the trigger for the neurodegenerative disease process is unknown, the relevance of aging stands out as a major risk for the development of neurodegeneration. In this review, we highlighted the relationship between the different cellular mechanisms that occur as a consequence of aging and transcription factor nuclear factor erythroid-2-related factor 2 (NRF2) and the connection with the TAU protein. We focused on the relevance of NRF2 in the main processes involved in neurodegeneration and associated with aging, such as genomic instability, protein degradation systems (proteasomes/autophagy), cellular senescence, and stem cell exhaustion, as well as inflammation. We also analyzed the effect of aging on TAU protein levels and its aggregation and spread process. Finally, we investigated the interconnection between NRF2 and TAU and the relevance of alterations in the NRF2 signaling pathway in both primary and secondary tauopathies. All these points highlight NRF2 as a possible therapeutic target for tauopathies. Brackhan M, Arribas-Blazquez M, Lastres-Becker I. Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration? Antioxidants (Basel). 2023 Aug 4;12(8):1564. doi: 10.3390/antiox12081564. PMID: 37627559; PMCID: PMC10451380. 10.3390/antiox12081564 https://hdl.handle.net/20.500.14352/96822 2076-3921 https://www.mdpi.com/2076-3921/12/8/1564 Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?