2026-06-27T23:18:37Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/968692025-03-18T13:35:10Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Montesinos Barceló, Andrés author Encinas Cerezo, María Teresa author Ardiaca, María author Gilabert Santos, Juan Antonio author Bonvehí, Cristina author Orós, Jorge 2024-01-31T08:34:23Z 2024-01-31T08:34:23Z 2019 Montesinos, A., Encinas, T., Ardiaca, M., Gilabert, J. A., Bonvehí, C., & Orós, J. (2019). Pharmacokinetics of meloxicam during multiple oral or intramuscular dose administration to African grey parrots (Psittacus erithacus). American journal of veterinary research, 80(2), 201–207. https://doi.org/10.2460/ajvr.80.2.201 0002-9645 10.2460/ajvr.80.2.201 https://hdl.handle.net/20.500.14352/96869 1943-5681 https://doi.org/10.2460/ajvr.80.2.201 30681357 OBJECTIVE To determine the pharmacokinetics of meloxicam in African grey parrots (Psittacus erithacus) during administration of multiple doses. ANIMALS 6 healthy African grey parrots. PROCEDURES Meloxicam was administered at each of 3 dosages (1 mg/kg, IM, q 24 h, for 7 days; 1 mg/kg, PO, q 24 h, for 12 days; and 1.6 mg/kg, PO, q 24 h, for 7 days) with an 8-week washout period between treatments. Blood samples were collected 12 and 24 hours after each drug administration (times of presumptive peak and trough drug concentrations) for pharmacokinetic analysis. Birds were visually assessed during all experiments and monitored for changes in selected plasma and urine biochemical variables after administration of the drug at 1.6 mg/kg. RESULTS Mean trough plasma concentrations at steady state were 10.7 and 9.16 µg/ mL after meloxicam administration at 1 mg/kg, IM, and 1 mg/kg, PO, respectively. Plasma drug accumulation was evident (accumulation ratios of 2.04 ± 0.30 [IM treatment] and 2.45 ± 0.26 [PO treatment]). Plasma and urine N-acetyl-β- D -glucosaminidase activities were significantly increased at the end of meloxicam treatment at 1.6 mg/kg. CONCLUSIONS AND CLINICAL RELEVANCE Plasma concentrations of meloxicam were maintained at values greater than effective analgesic concentrations described for other avian species. Although administration of meloxicam at a dosage of 1 mg/kg IM and PO daily for 1 week and 12 days, respectively, was not associated with adverse clinical effects in this population, further studies are needed to assess the efficacy and safety of the drug during prolonged treatment and the clinical relevance of its accumulation. eng Attribution-NonCommercial-NoDerivatives 4.0 International Pharmacokinetics of meloxicam during multiple oral or intramuscular dose administration to African grey parrots (Psittacus erithacus) journal article 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URL https://docta.ucm.es/bitstreams/7a3364ee-965b-44d2-baaa-cbb61f29331d/download File MD5 59e6da413793525163a842bd7b1558a3 291113 application/pdf Pharmacokinetics_of_meloxicam.pdf URL https://docta.ucm.es/bitstreams/daeccb0c-2ac0-456e-a71e-50b711c0d1db/download File MD5 233a8b9f32146ab7fda9a78ea3681ca3 37056 text/plain Pharmacokinetics_of_meloxicam.pdf.txt