2026-06-27T11:25:20Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/970102024-08-10T00:04:05Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Ventimiglia, Leandro author Fernández-Martín, Laura author Martínez-Alonso, Emma author Antón Hurtado, Olga María author Guerra, Milagros author Martínez-Menárguez, José Angel author Andrés, Germán author Alonso, Miguel 2024-01-31T10:58:53Z 2024-01-31T10:58:53Z 2015 Leandro N. Ventimiglia, Laura Fernández-Martín, Emma Martínez-Alonso, Olga M. Antón, Milagros Guerra, José Angel Martínez-Menárguez, Germán Andrés, Miguel A. Alonso; Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells. J Immunol 1 August 2015; 195 (3): 810–814. https://doi.org/10.4049/jimmunol.1500891 0022-1767 10.4049/jimmunol.1500891 https://hdl.handle.net/20.500.14352/97010 1550-6606 https://doi.org/10.4049/jimmunol.1500891 Exosomes secreted by T cells play an important role in coordinating the immune response. HIV-1 Nef hijacks the route of exosome secretion of T cells to modulate the functioning of uninfected cells. Despite the importance of the process, the protein machinery involved in exosome biogenesis is yet to be identified. In this study, we show that MAL, a tetraspanning membrane protein expressed in human T cells, is present in endosomes that travel toward the plasma membrane for exosome secretion. In the absence of MAL, the release of exosome particles and markers was greatly impaired. This effect was accompanied by protein sorting defects at multivesicular endosomes that divert the exosomal marker CD63 to autophagic vacuoles. Exosome release induced by HIV-1 Nef was also dependent on MAL expression. Therefore, MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells. eng Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells journal article 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URL https://docta.ucm.es/bitstreams/01eced86-54f2-4120-b21e-9f39c5ce89d6/download File MD5 4da441af91f704a9fc0c8dafb7c8b7dc 2156751 application/pdf Regulation_of_Exosome_Secretion.pdf