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oai:docta.ucm.es:20.500.14352/970282025-03-18T13:10:44Zcom_20.500.14352_14col_20.500.14352_15

Martínez Caballero, María Aranzazu Ares Lombán, Irma Rodríguez, José Luis Martínez Caballero, Marta Martínez Larrañaga, María Rosa Anadón Navarro, Arturo Ramón 2024-01-31T11:26:57Z 2024-01-31T11:26:57Z 2018 Martínez, M. A., Ares, I., Rodríguez, J. L., Martínez, M., Martínez-Larrañaga, M. R., & Anadón, A. (2018). Neurotransmitter changes in rat brain regions following glyphosate exposure. Environmental research, 161, 212–219. https://doi.org/10.1016/j.envres.2017.10.051 0013-9351 10.1016/j.envres.2017.10.051 https://hdl.handle.net/20.500.14352/97028 https://doi.org/10.1016/j.envres.2017.10.051 29156344 The effects of glyphosate oral exposure (35, 75, 150 and 800 mg/kg bw, 6 days) on brain region monoamine levels of male Wistar rats were examined. Glyphosate-treated rats (35, 75, 150 and 800 mg/kg bw, 6 days), had no visible injury, i.e., no clinical signs of dysfunction were observed. After last dose of glyphosate, serotonin (5-HT), dopamine (DA) and norepinephrine (NE) and its metabolites levels were determined in the brain regions striatum, hippocampus, prefrontal, cortex, hypothalamus and midbrain, by HPLC. Glyphosate caused statistically significant changes in the 5-HT and its metabolite 5-hydroxy-3-indolacetic acid (5-HIAA), DA and its metabolites 3,4-hydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and NE and its metabolite 3-metoxy-4-hydroxyphenylethyleneglycol (MHPG) levels in a brain regional- and dose-related manner. Moreover, glyphosate, dose-dependent, evoked a statistically significant increase in 5-HT turnover in striatum and hypothalamus and in DA turnover in prefrontal cortex and hippocampus, and a statistically significant decrease in NE turnover in prefrontal cortex and hypothalamus. The present findings indicate that glyphosate significantly altered central nervous system (CNS) monoaminergic neurotransmitters in a brain regional- and dose-related manner, effects that may contribute to the overall spectrum of neurotoxicity caused by this herbicide. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ restricted access Attribution-NonCommercial-NoDerivatives 4.0 International Neurotransmitter changes in rat brain regions following glyphosate exposure journal article