2026-06-26T17:11:40Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/972392025-03-18T11:52:35Zcom_20.500.14352_14col_20.500.14352_15

Dosil, Sara Rodríguez-Galán, Ana Sánchez-Madrid, Francisco Fernández Messina, Lola María 2024-01-31T14:03:26Z 2024-01-31T14:03:26Z 2022 Dosil, S.G.; Rodríguez-Galán, A.; Sánchez-Madrid, F.; Fernández-Messina, L. MicroRNAs in T Cell-Immunotherapy. Int. J. Mol. Sci. 2023, 24, 250. https://doi.org/10.3390/ijms24010250 10.3390/ijms24010250 https://hdl.handle.net/20.500.14352/97239 1422-0067 https://doi.org/10.3390/ijms24010250 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820302/ MicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies. eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International MicroRNAs in T Cell-Immunotherapy journal article