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oai:docta.ucm.es:20.500.14352/974922025-09-05T23:57:31Zcom_20.500.14352_14col_20.500.14352_15

Casanova, Javier Garutti Martínez, Ignacio Simón Adiego, Carlos María Giraldez, Ana Martín, Beatriz González Casaurrán, Guillermo Azcárate Perea, Leire García Martín, M. Cruz Vara Ameigeiras, Elena María 2024-02-01T09:07:57Z 2024-02-01T09:07:57Z 2011 Casanova J, Garutti I, Simon C, Giraldez A, Martin B, Gonzalez G, Azcarate L, Garcia C, Vara E. The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs. Anesth Analg. 2011 Oct;113(4):742-8. doi: 10.1213/ANE.0b013e3182288e01. Epub 2011 Sep 2. PMID: 21890883. 0003-2999 10.1213/ANE.0b013e3182288e01 https://hdl.handle.net/20.500.14352/97492 https://doi.org/10.1213/ANE.0b013e3182288e01 21890883 https://pubmed.ncbi.nlm.nih.gov/21890883/ Background: Ischemia-reperfusion lung injury is doubly important in thoracic surgery because of the associated ventilation damage to 1 lung. In this study we evaluated the cytoprotective effects of sevoflurane in a pulmonary autotransplant model in pigs. Methods: Twenty Large White pigs undergoing pneumonectomy plus lung autotransplant were divided into 2 10-member groups on the basis of the anesthetic received (propofol or sevoflurane). Proinflammatory mediators, oxidative stress, nitric oxide metabolism, and hemodynamic and blood variables were measured at 5 different time points. Results: There was an increase of oxidative stress markers and proinflammatory mediators in the propofol group, whereas the hemodynamic variables were similar in both groups. Conclusions: We demonstrated that sevoflurane decreased the inflammatory response and oxidative stress in a live ischemia-reperfusion lung model. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ restricted access Attribution-NonCommercial-NoDerivatives 4.0 International The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs journal article