2026-06-27T01:08:42Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/977372024-09-27T23:57:52Zcom_20.500.14352_14col_20.500.14352_15

Luque, Jordi Torres, María Isabel Aumente, María Dolores Marín, José García-Jurado, Gema González, Rafael Pascual, Domingo Guerra Pérez, Natalia López-Rubio, Fernando Alvarez-López, Rocío Arizón, José Peña, José 2024-02-01T13:16:31Z 2024-02-01T13:16:31Z 2006 Luque, J., et al. «Soluble HLA-G in Heart Transplantation: Their Relationship to Rejection Episodes and Immunosuppressive Therapy». Human Immunology, vol. 67, n.o 4-5, abril de 2006, pp. 257-63. https://doi.org/10.1016/j.humimm.2006.02.034. 0198-8859 10.1016/j.humimm.2006.02.034 https://hdl.handle.net/20.500.14352/97737 1879-1166 https://doi.org/10.1016/j.humimm.2006.02.034 https://www.sciencedirect.com/science/article/pii/S0198885906000218?via%3Dihub The aims of this study were to quantify the level of soluble HLA-G in heart transplant patients, to determine the relationship between the sHLA-G levels and the appearance of acute rejection episodes, and to identify the influence of immunosuppressive therapy on sHLA-G levels. Analysis of sHLA-G, measured by enzyme-linked immunosorbent assay in the transplant patients, revealed the existence of two similarly sized groups of patients. One group displayed a significant increase (p < 0.001) in sHLA-G during the first month after transplantation while the other group maintained low levels of the molecule (0–30 ng/ml) throughout the study. The latter group displayed a high incidence of recurrent severe rejection. A significant increase (p < 0.01) in sHLA-G 2 hours after administration of immunosuppressive treatment (mycophenolate mofetil, cyclosporine A/FK506, corticoids) was found. These results suggest that sHLA-G participates in the induction of certain levels of immunological tolerance in these recipients. eng http://creativecommons.org/licenses/by-nd/4.0/ restricted access Attribution-NoDerivatives 4.0 International Soluble HLA-G in heart transplantation: their relationship to rejection episodes and immunosuppressive therapy journal article