2026-06-27T01:06:56Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/977862025-03-18T15:55:21Zcom_20.500.14352_14col_20.500.14352_15

Salazar Roa, María Carracedo, Arkaitz Salanueva, Íñigo Hernández Tiedra, Sonia Egia, Ainara Lorente Pérez, María Del Mar Vázquez, Patricia Torres, Sofia Iovanna, Juan Guzmán Pastor, Manuel Boya, Patricia Velasco Díez, Guillermo 2024-02-01T13:54:52Z 2024-02-01T13:54:52Z 2009 Salazar, M., Carracedo, A., Salanueva, Í. J., Hernández-Tiedra, S., Egia, A., Lorente, M., … Velasco, G. (2009). TRB3 links ER stress to autophagy in cannabinoid antitumoral action. Autophagy, 5(7), 1048–1049. https://doi.org/10.4161/auto.5.7.9508 1554-8627 10.4161/auto.5.7.9508 https://hdl.handle.net/20.500.14352/97786 1554-8635 https://doi.org/10.4161/auto.5.7.9508 Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, is being investigated as a potential anti-tumoral agent. We find that THC stimulates an endoplasmic reticulum (ER) stress-related signaling pathway, which activates autophagy via inhibition of the Akt/mTORC1 axis. We also show that autophagy is upstream of apoptosis in cannabinoid-induced cancer cell death and that activation of this pathway is necessary for the anti-tumoral action of cannabinoids in vivo. eng restricted access TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action journal article