2026-06-27T10:55:15Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/978102025-05-12T23:50:25Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Góngora, Rafael author Corell, Alfredo author Regueiro, Jose R author Carasol, Miguel author Rodríguez-Gallego, Carlos author Paz Artal, Estela Natividad author Timón, Marcos author Allende Martínez, Luis Miguel author Arnaiz Villena, Antonio 2024-02-01T14:37:02Z 2024-02-01T14:37:02Z 1994 Góngora R, Corell A, Regueiro JR, Carasol M, Rodríguez-Gallego C, Paz-Artal E, Timón M, Allende L, Arnaiz-Villena A. Peripheral blood reduction of memory (CD29+, CD45RO+, and "bright" CD2+ and LFA-1+) T lymphocytes in Papillon-Lefèvre syndrome. Hum Immunol. 1994 Nov;41(3):185-92. doi: 10.1016/0198-8859(94)90035-3. PMID: 7532641. 0198-8859 10.1016/0198-8859(94)90035-3 https://hdl.handle.net/20.500.14352/97810 https://doi.org/10.1016/0198-8859(94)90035-3 A Papillon-Lefèvre patient with characteristic chronic periodontal disease and palmoplantar keratoderma was studied over a 4-year period. An abnormal T-cell phenotype was steadily observed in peripheral blood; both low numbers of CD29+ and CD45RO+ cells and a low density surface expression of CD2 and LFA-1 molecules were found. T-cell activation through CD3, CD2 and ConA, PWM and IL-2 receptors was normal; however, there was impairment in the activation via CD28. CD2, LFA-1 and CD45 molecules were normal in charge and molecular weight. There was no tissue sequestering of T lymphocytes in periodontal lesions, but rather a relative T-cell reduction. It is suggested that an important decrease of the so-called "memory/hyperreactive" (CD45RO-positive) T cells does exist; therefore, hyperreactive T cells would not be available in sufficient numbers to leave the bloodstream through blood vessel endothelium, and the periodontium would be left without these important defenses and thus exposed to chronic infections. A disregulated factor affecting the transition from "naive" to "memory" T cells and the increase in certain surface molecules expression (i.e., CD2, LFA-1, CD29, and CD45RO) or the reversion from memory to naive T cells may be responsible for the disease pathogenesis. CD2 and LFA-1 molecule synthesis might be conjointly regulated on T lymphocytes. eng Peripheral blood reduction of memory (CD29+, CD45RO+, and “Bright” CD2+ and LFA-1+) T lymphocytes in Papillon-Lefèvre syndrome journal article 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