2026-06-27T15:26:38Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/978192025-09-06T00:00:44Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Arnaiz Villena, Antonio author Martinez‐Laso, Jorge author Corell, Alfredo author Rosal, M. author Allende Martínez, Luis Miguel author Gómez-Reino Carnota, Juan author Vicario, José Luis 2024-02-01T14:58:20Z 2024-02-01T14:58:20Z 1996 Arnaiz-Villena A, Martinez-Laso J, Corell A, Allende L, Rosal M, Gomez-Reino JJ, Vicario JL. Frequencies of HLA-A24 and HLA-DR4-DQ8 are increased and that of HLA-B blank is decreased in chronic toxic oil syndrome. Eur J Immunogenet. 1996 Jun;23(3):211-9. doi: 10.1111/j.1744-313x.1996.tb00116.x. PMID: 8803534. 1744-3121 10.1111/j.1744-313x.1996.tb00116.x https://hdl.handle.net/20.500.14352/97819 1744-313X https://doi.org/10.1111/j.1744-313X.1996.tb00116.x SUMMARY: The cause of toxic oil syndrome (TOS) has not yet been definitively determined, but some genetic susceptibility factors (certain HLA antigens and female sex) have been identified in 236 patients. Similarities with genetic factors for scleroderma and hydralazine‐induced lupus (i.e. in TOS female sex and HLA‐A24, P<= 0.00001 and DR4, P< 0.04, respectively) may provide a clue to the responsible xenobiotic and its pathogenesis, and may also help in understanding the basis of the related eosinophilia‐myalgia syndrome associated with tryptophan ingestion. In this paper it is also established that a human class I antigen (HLA‐A24) and, independently, an HLA class II haplotype (DR4‐DQ8, P<0.04) and arginine 52 in the α‐DQ chains (P<0.03) are associated with TOS susceptibility, similarly to insulin‐dependent diabetes. This further supports the classification of TOS as an autoimmune disease. Also, the increased frequency of a particular set of low‐frequency HLA class I antigens in chronic TOS patients (i.e. B27, B37, B38 and B49) and the probable decrease in the frequency of HLA‐B homozygotes in surviving patients (P<0.008) may provide an objective model to explain the maintenance of the HLA polymorphism: less frequent HLA alleles may be more advantageous in the event of unexpected human contact with unusual xenobiotics (not only microbes); however, other mechanisms working together to preserve and generate HLA polymorphism may coexist. eng Attribution-NonCommercial-NoDerivatives 4.0 International Frequencies of HLA-A24 and HLA-DR4-DQ8 are increased and that of HLA-B blank is decreased in chronic toxic oil syndrome journal article 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URL https://docta.ucm.es/bitstreams/9b459bf9-4cf4-4027-a76e-c60b0bfc62f8/download File MD5 75ca48ebc4f6e6fe0003c6883623e18d 588300 application/pdf HLA-A24.pdf URL https://docta.ucm.es/bitstreams/24c92e8d-00d4-4cc7-b07e-0da535c8e888/download File MD5 3a8dda18ad37fdada912a98005f9260e 31327 text/plain A24 OIL TOXIC.pdf.txt