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oai:docta.ucm.es:20.500.14352/978782025-09-02T13:00:49Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Flores Perojo, Vicente author Macías Rodríguez, Ricardo U. author Ruiz Margáin, Astrid author Regueiro González-Barros, José Ramón author Ávila, Matias A author Trautwein, Christian author Bañares Cañizares, Rafael author Bosch, Jaume author Estévez Vázquez, Olga author Martínez Naves, Eduardo author Cubero Palero, Francisco Javier author Nevzorova, Yulia author Benede Ubieto, Raquel author 2021 Abstract: The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients. Benedé-Ubieto R, Estévez-Vázquez O, Flores-Perojo V, Macías-Rodríguez RU, Ruiz-Margáin A, Martínez-Naves E, Regueiro JR, Ávila MA, Trautwein C, Bañares R, Bosch J, Cubero FJ, Nevzorova YA. Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain. J Clin Med. 2021 Mar 3;10(5):1039. doi: 10.3390/jcm10051039. PMID: 33802486; PMCID: PMC7959465. 10.3390/ jcm10051039 https://hdl.handle.net/20.500.14352/97878 2077-0383 https://doi.org/10.3390/ jcm10051039 https://www.mdpi.com/2077-0383/10/5/1039 Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain