2026-08-20T06:01:14Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/978782025-09-02T13:00:49Zcom_20.500.14352_14col_20.500.14352_15
Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain
Flores Perojo, Vicente
Macías Rodríguez, Ricardo U.
Ruiz Margáin, Astrid
Regueiro González-Barros, José Ramón
Ávila, Matias A
Trautwein, Christian
Bañares Cañizares, Rafael
Bosch, Jaume
Estévez Vázquez, Olga
Martínez Naves, Eduardo
Cubero Palero, Francisco Javier
Nevzorova, Yulia
Benede Ubieto, Raquel
Abstract: The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes
in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.
2024-02-01T15:49:25Z
2024-02-01T15:49:25Z
2024-02-01T15:49:25Z
2021
journal article
https://hdl.handle.net/20.500.14352/97878
XXXX-XXXX
10.3390/ jcm10051039
2077-0383
eng
info:eu-repo/grantAgreement/MINECO//PI16%2F01126/ES/Nuevas aproximaciones experimentales al diagnóstico y tratamiento del colangiocarcinoma/
58/17
SAF2014-54708-R
SAF2016- 78711
SAF2017-87919-R
EXOHEP-CM S2017/BMD-3727
NanoLiver-CM Y2018/NMT-4949
ERAB Ref. EA 18/14
AMMF 2018/117
UCM 25/2019
COST Action CA17112
SFB/TRR57/P04
SFB 1382-403224013/A02
DFG NE 2128/2-1
RYC-2014-15242
info:eu-repo/grantAgreement/MINECO//RYC-2015-17438/ES/RYC-2015-17438/
CT82/20-CT83/20
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-87919-R/ES/INTERDEPENDENCIA DEL ESTRES OXIDATIVO Y LA INFLAMACION DURANTE LA ENFERMEDAD HEPATICA CRONICA: UNA NUEVA HERRAMIENTA TERANOSTICA/
Benedé-Ubieto R, Estévez-Vázquez O, Flores-Perojo V, Macías-Rodríguez RU, Ruiz-Margáin A, Martínez-Naves E, Regueiro JR, Ávila MA, Trautwein C, Bañares R, Bosch J, Cubero FJ, Nevzorova YA. Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain. J Clin Med. 2021 Mar 3;10(5):1039. doi: 10.3390/jcm10051039. PMID: 33802486; PMCID: PMC7959465.
http://creativecommons.org/licenses/by-nc-nd/4.0/
open access
Attribution-NonCommercial-NoDerivatives 4.0 International
MDPI