2026-08-21T00:04:52Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/978782025-09-02T13:00:49Zcom_20.500.14352_14col_20.500.14352_15

Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain Flores Perojo, Vicente Macías Rodríguez, Ricardo U. Ruiz Margáin, Astrid Regueiro González-Barros, José Ramón Ávila, Matias A Trautwein, Christian Bañares Cañizares, Rafael Bosch, Jaume Estévez Vázquez, Olga Martínez Naves, Eduardo Cubero Palero, Francisco Javier Nevzorova, Yulia Benede Ubieto, Raquel Abstract: The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients. 2024-02-01T15:49:25Z 2024-02-01T15:49:25Z 2021 journal article Benedé-Ubieto R, Estévez-Vázquez O, Flores-Perojo V, Macías-Rodríguez RU, Ruiz-Margáin A, Martínez-Naves E, Regueiro JR, Ávila MA, Trautwein C, Bañares R, Bosch J, Cubero FJ, Nevzorova YA. Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain. J Clin Med. 2021 Mar 3;10(5):1039. doi: 10.3390/jcm10051039. PMID: 33802486; PMCID: PMC7959465. 10.3390/ jcm10051039 https://hdl.handle.net/20.500.14352/97878 2077-0383 https://doi.org/10.3390/ jcm10051039 https://www.mdpi.com/2077-0383/10/5/1039 eng info:eu-repo/grantAgreement/MINECO//PI16%2F01126/ES/Nuevas aproximaciones experimentales al diagnóstico y tratamiento del colangiocarcinoma/ 58/17 SAF2014-54708-R SAF2016- 78711 SAF2017-87919-R EXOHEP-CM S2017/BMD-3727 NanoLiver-CM Y2018/NMT-4949 ERAB Ref. EA 18/14 AMMF 2018/117 UCM 25/2019 COST Action CA17112 SFB/TRR57/P04 SFB 1382-403224013/A02 DFG NE 2128/2-1 RYC-2014-15242 info:eu-repo/grantAgreement/MINECO//RYC-2015-17438/ES/RYC-2015-17438/ CT82/20-CT83/20 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-87919-R/ES/INTERDEPENDENCIA DEL ESTRES OXIDATIVO Y LA INFLAMACION DURANTE LA ENFERMEDAD HEPATICA CRONICA: UNA NUEVA HERRAMIENTA TERANOSTICA/ http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 International MDPI