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oai:docta.ucm.es:20.500.14352/979292025-04-01T00:05:23Zcom_20.500.14352_14col_20.500.14352_15

Anadón Navarro, Arturo Ramón Suarez, Frank Martínez Caballero, María Aranzazu Castellano Santos, Víctor Jesús Martínez Caballero, Marta Ares Lombán, Irma Ramos Alonso, Eva Gamboa, Felipe Martínez Larrañaga, María Rosa 2024-02-01T17:21:28Z 2024-02-01T17:21:28Z 2011 Anadón A, Suárez FH, Martínez MA, Castellano V, Martínez M, Ares I, Ramos E, Gamboa F, Martínez-Larrañaga MR. Plasma disposition and tissue depletion of difloxacin and its metabolite sarafloxacin in the food producing animals, chickens for fattening. Food Chem Toxicol. 2011 Feb;49(2):441-9. doi: 10.1016/j.fct.2010.11.021. Epub 2010 Nov 23. PMID: 21108984. 0278-6915 10.1016/j.fct.2010.11.021 https://hdl.handle.net/20.500.14352/97929 1873-6351 https://doi.org/10.1016/j.fct.2010.11.021 21108984 Chickens were used to investigate plasma disposition of difloxacin after single intravenous (IV) and oral dose (10 mg/kg body weight (BW)) and to study residue depletion of difloxacin and its major metabolite sarafloxacin after multiple oral doses (10 mg difloxacin/kg BW, daily for 5 days). Plasma and tissue samples were analyzed using a HPLC method. After IV and oral administration, plasma drug concentration-time curves were best described by a two-compartment open model. Mean (± SD) elimination half-lives (t(½)β) of difloxacin were 9.53±1.00 and 12.23±1.81 h after IV and oral administration. Maximum plasma concentration was 2.34±0.50 μg/ml and interval from oral administration until maximal concentration was 1.34±0.03 h. Oral bioavailability was found to be 68.89±15.21%. Difloxacin was converted to sarafloxacin. After multiple oral dose (10mg difloxacin/kg BW, daily for 5 days), mean kidney, liver, muscle and skin + fat tissue concentrations of difloxacin and sarafloxacin ranging between 604.8±132.5 and 368.1±52.5 μg/kg and 136.4±18.3 and 10.4±1.2 μg/kg, respectively, were measured 1 day after administration of the final dose of difloxacin. A withdrawal time of 5 days was necessary to ensure that the residues of difloxacin were less than the maximal residue limits (MRL) or tolerance established by the European Union. eng restricted access Plasma disposition and tissue depletion of difloxacin and its metabolite sarafloxacin in the food producing animals, chickens for fattening journal article