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00925njm 22002777a 4500 dc Quintana Villamandos, María Begoña author Rodríguez Bernal, Guillermo Juan author Pérez Caballero, Ramón author Otero, Javier author Ruiz Fernández, Manuel author Delgado Martos, María Jesús author Sánchez Hernández, José Javier author Delgado Baeza, Emilio author Cañizo López, Juan Francisco Del author 2012-01-01 We describe the placement of a left ventricular assist device (LVAD) in a pig with spontaneously occurring atrial septal defect (ASD) (incidental finding) that created a right-left cardiac shunt, with subsequent severe hypoxaemia. Early diagnosis was critical in order to prevent end-organ damage due to hypoxaemia. Adequate monitoring alerted us to the deterioration in oxygenation, haemodynamics and cerebral oxygen metabolism. This forced us to change the level of assistance provided by the pump, and thus dramatically correct this impairment. Necropsy revealed an ostium secundum ASD. In conclusion, if hypoxaemia presents after implementation of an LVAD, the presence of a right-left shunt must be ruled out. The first step must be a judicious reduction in assist device flow to minimize intracardiac shunting. Subsequently, atrial septal closure of the defect should be considered. We report an experimental model of severe hypoxaemia after placement of an LVAD as part of a larger research project Quintana-Villamandos B, Rodríguez-Bernal GJ, Pérez-Caballero R, Otero J, Ruiz M, Delgado-Martos MJ, Sánchez-Hernández JJ, Delgado-Baeza E, Del Cañizo JF. Severe hypoxaemia with a left ventricular assist device in a minipig model with an undiagnosed congenital cardiac disease. Lab Anim. 2012 Jan;46(1):77-80. doi: 10.1258/la.2011.011067 0023-6772 10.1258/la.2011.011067 https://hdl.handle.net/20.500.14352/98036 0023-6772 https://journals.sagepub.com/doi/10.1258/la.2011.011067?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed https://pubmed.ncbi.nlm.nih.gov/22072625/ Severe hypoxaemia with a left ventricular assist device in a minipig model with an undiagnosed congenital cardiac disease