2026-06-28T20:10:41Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/980382025-04-01T00:14:20Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Anadón Navarro, Arturo Ramón author Martínez Caballero, María Aranzazu author Martínez Caballero, Marta author Ríos, Alba author Caballero, Virginia author Ares Lombán, Irma author Martínez Larrañaga, María Rosa 2024-02-02T07:44:56Z 2024-02-02T07:44:56Z 2008 Anadón A, Martínez MA, Martínez M, Ríos A, Caballero V, Ares I, Martínez-Larrañaga MR. Plasma and tissue depletion of florfenicol and florfenicol-amine in chickens. J Agric Food Chem. 2008 Nov 26;56(22):11049-56. doi: 10.1021/jf802138y. PMID: 18975969. 0021-8561 10.1021/jf802138y https://hdl.handle.net/20.500.14352/98038 1520-5118 https://doi.org/10.1021/jf802138y Chickens were used to investigate plasma disposition of florfenicol after single intravenous (i.v.) and oral dose (20 mg kg-1 body weight) and to study residue depletion of florfenicol and its major metabolite florfenicol-amine after multiple oral doses (40 mg kg-1 body weight, daily for 3 days). Plasma and tissue samples were analyzed using a high-performance liquid chromatography (HPLC) method. After i.v. and oral administration, plasma concentration-time curves were best described by a two-compartment open model. The mean [ +/- standard deviation (SD)] elimination half-life (t1/2beta) of florfenicol in plasma was 7.90 +/- 0.48 and 8.34 +/- 0.64 h after i.v. and oral administration, respectively. The maximum plasma concentration was 10.23 +/- 1.67 microg mL-1, and the interval from oral administration until maximal concentration was 0.63 +/- 0.07 h. Oral bioavailability was found to be 87 +/- 16%. Florfenicol was converted to florfenicol-amine. After multiple oral dose (40 mg kg-1 body weight, daily for 3 days), in kidney and liver, concentrations of florfenicol (119.34 +/- 31.81 and 817.34 +/- 91.65 microg kg-1, respectively) and florfenicol-amine (60.67 +/- 13.05 and 48.50 +/- 13.07 microg kg-1, respectively) persisted for 7 days. The prolonged presence of residues of florfenicol and florfenicol-amine in edible tissues can play an important role in human food safety, because the compounds could give rise to a possible health risk. A withdrawal time of 6 days was necessary to ensure that the residues of florfenicol were less than the maximal residue limits or tolerance established by the European Union. eng Plasma and Tissue Depletion of Florfenicol and Florfenicol-amine in Chickens journal article 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URL https://docta.ucm.es/bitstreams/8b2f171b-cced-4011-84ea-72631955f659/download File MD5 abd800b3d790400b1f2e0287e45678ce 495463 application/pdf Plasma_Tissue_Depletion.pdf