2026-07-03T06:33:38Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/982882025-09-18T15:58:57Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Medrano García, Sandra author Morales Cano, Daniel author Barreira, Bianca author Pérez Vizcaíno, Francisco author Fernández Malavé, Edgar Gonzalo author Cogolludo Torralba, Ángel Luis 2024-02-02T12:54:11Z 2024-02-02T12:54:11Z 2022 Medrano-Garcia S, Morales-Cano D, Barreira B, Vera-Zambrano A, Kumar R, Kosanovic D, Schermuly RT, Graham BB, Perez-Vizcaino F, Mathie A, Savai R, Pullamseti S, Butrous G, Fernández-Malavé E, Cogolludo A. HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape. Cells. 2022 Aug 4;11(15):2414. doi: 10.3390/cells11152414 2073-4409 10.3390/cells11152414 https://hdl.handle.net/20.500.14352/98288 https://doi.org/10.3390/cells11152414 https://www.mdpi.com/2073-4409/11/15/2414https://pubmed.ncbi.nlm.nih.gov/35954255/ HIV and Schistosoma infections have been individually associated with pulmonary vascular disease. Co-infection with these pathogens is very common in tropical areas, with an estimate of six million people co-infected worldwide. However, the effects of HIV and Schistosoma co-exposure on the pulmonary vasculature and its impact on the development of pulmonary vascular disease are largely unknown. Here, we have approached these questions by using a non-infectious animal model based on lung embolization of Schistosoma mansoni eggs in HIV-1 transgenic (HIV) mice. Schistosome-exposed HIV mice but not wild-type (Wt) counterparts showed augmented pulmonary arterial pressure associated with markedly suppressed endothelial-dependent vasodilation, increased endothelial remodeling and vessel obliterations, formation of plexiform-like lesions and a higher degree of perivascular fibrosis. In contrast, medial wall muscularization was similarly increased in both types of mice. Moreover, HIV mice displayed an impaired immune response to parasite eggs in the lung, as suggested by decreased pulmonary leukocyte infiltration, small-sized granulomas, and augmented residual egg burden. Notably, vascular changes in co-exposed mice were associated with increased expression of proinflammatory and profibrotic cytokines, including IFN-γ and IL-17A in CD4+ and γδ T cells and IL-13 in myeloid cells. Collectively, our study shows for the first time that combined pulmonary persistence of HIV proteins and Schistosoma eggs, as it may occur in co-infected people, alters the cytokine landscape and targets the vascular endothelium for aggravated pulmonary vascular pathology. Furthermore, it provides an experimental model for the understanding of pulmonary vascular disease associated with HIV and Schistosoma co-morbidity. eng Attribution 4.0 International HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape journal article 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URL https://docta.ucm.es/bitstreams/0cd6c346-7d31-4b63-b117-dfd15c8e577a/download File MD5 2079d25f9b758644cff98b8f0915cba7 3558204 application/pdf Medrano_Garcia_Cells.pdf URL https://docta.ucm.es/bitstreams/0daad071-c4f3-426d-8790-d6d248e9029d/download File MD5 e7615945ef5dd51b6b350b1597c00b21 98414 text/plain Medrano_Garcia_Cells.pdf.txt