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oai:docta.ucm.es:20.500.14352/984562024-06-29T00:11:23Zcom_20.500.14352_14col_20.500.14352_15

Synthesis and stereoselective lithiation of enantiopure 2‐(1‐aminoalkyl)aziridine–borane complexes Concellón, José M. Suárez Álvarez, José Ramón García‐Granda, Santiago Díaz, M. Rosario This work shows that the enantiopure 2-(1-aminoalkyl)aziridine–borane complexes can easily be obtained by two alternative methodologies: either reaction with BF3·Et2O followed by reduction with LiAlH4 or by direct reaction with a solution of BH3 in THF. In addition, regio- and stereoselective C3 deuteration or silylation of 2-(1- aminoalkyl)aziridine 1 can be effected by eprotonation/ deuteration or silylation/decomplexation of the corresponding borane complex 2. Application of this methodology to functionalize 2-(1-aminoalkyl)aziridines with other different electrophiles is currently under investigation. 2024-02-02T17:15:27Z 2024-02-02T17:15:27Z 2024-02-02T17:15:27Z 2004 journal article https://hdl.handle.net/20.500.14352/98456 1433-7851 10.1002/anie.200460120 1521-3773 eng info:eu-repo/grantAgreement/BQU2001-3807 Concellón, J. M., Suárez, J. R., García‐Granda, S., & Díaz, M. R. (2004). Synthesis and Stereoselective Lithiation of Enantiopure 2‐(1‐Aminoalkyl) aziridine–Borane Complexes. Angewandte Chemie, 116(33), 4433-4436. restricted access Wiley-VCH Verlag GmbH & Co