2026-06-28T20:09:28Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/987882024-02-17T01:14:10Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Pérez Castellano, Nicasio author Pérez Villacastín Domínguez, Julián author Aragoncillo Ballesteros, Paloma author Fantidis, Panayotis author Sabaté, Manel author García Torrent, María Jesús author Prieto Martín, Carlos author Corral, José M. author Moreno, Javier author Fernández Ortiz, Antonio Ignacio author Vaño Carruana, Eliseo author Macaya Miguel, Carlos 2024-02-05T10:35:29Z 2024-02-05T10:35:29Z 2006-06-01 Pérez-Castellano N, Villacastín J, Aragoncillo P, Fantidis P, Sabaté M, García-Torrent MJ, Prieto C, Corral JM, Moreno J, Fernández-Ortiz A, Vano E, Macaya C. Pathological effects of pulmonary vein beta-radiation in a swine model. J Cardiovasc Electrophysiol. 2006 Jun;17(6):662-9. doi: 10.1111/j.1540-8167.2006.00462.x. PMID: 16836719. 1045-3873 10.1111/j.1540-8167.2006.00462.x https://hdl.handle.net/20.500.14352/98788 https://onlinelibrary.wiley.com/doi/10.1111/j.1540-8167.2006.00462.x 6836719 https://pubmed.ncbi.nlm.nih.gov/16836719/ Introduction: Atrial fibrillation (AF) may be triggered by ectopic beats originating in sleeves of atrial myocardium entering the pulmonary veins (PVs). PV isolation by means of circumferential ostial or atrial radiofrequency ablation is an effective but also a difficult and long procedure, requiring extensive applications that can have serious potential complications. Our objective was to examine pathological effects of PV β-radiation, particularly the ability to destroy PV myocardial sleeves without inducing PV stenosis and other unwanted effects, in order to establish its potential feasibility for the treatment of AF. Methods and Results: Ten minipigs were studied. A phosphorus-32 source wire centered within a 2.5-mm diameter balloon catheter (Galileo® III Intravascular Radiotherapy System, Guidant, Santa Clara, CA, USA) was used to deliver β-radiation to the superior wall of the right PV trunk. Pathological analysis was performed either immediately after ablation (2 pigs) or 81 ± 27 days later (8 pigs). Acute effects of PV β-radiation consisted of endothelial denudation covered by white thrombus, elastic lamina disruption, and PV sleeve necrosis. Late effects consisted of mild focal neointimal hyperplasia that reduced the PV luminal area by only 1.3 ± 1.8%, elastic lamina thickening, and PV sleeve fibrosis. Four of these 8 PVs were completely re-endothelized. Lesions were transmural in 6 of 10 radiated PVs and segmental, involving 28 ± 7% of the right PV perimeter. Conclusion: Intravascular β-radiation can induce transmural necrosis and fibrosis of PV myocardial sleeves without PV stenosis and other unwanted effects, which supports a potential usefulness of this energy source in the treatment of AF. eng Pathological effects of pulmonary vein beta-radiation in a swine model journal article 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URL https://docta.ucm.es/bitstreams/5672ba40-ca3b-4ed1-b84a-a6326d5b72f8/download File MD5 4db1b006060727d48fb34aaef652bbdc 362683 application/pdf 2006_Journal_of_Cardiovascular_Electrophysiology_Pathological_JPV_.pdf