2026-06-08T08:37:06Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/989052025-03-18T12:06:39Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Rodríguez-Torrado, Marta
author
Kara, Aytug
author
Romero Martínez, Manuel Alejandro
author
Juberías, Antonio
author
Torrado Durán, Juan José
author
Serrano López, Dolores Remedios
2024-02-05T12:15:37Z
2024-02-05T12:15:37Z
2022-11-26
1999-4923
10.3390/pharmaceutics14122615
https://hdl.handle.net/20.500.14352/98905
Oily excipients are vital components of dermatological products. In this study, the in vitro and in vivo characteristics of Wild Olive Oil (WOO) were compared with two other types of olive oils: Extra Virgin Olive Oil (EVOO) and Virgin Olive Oil (VOO). This work has also included Liquid Paraffin (LP) and Rosehip Oil (RO) as reference oils. Melatonin was used in the study as a model drug to demonstrate the antioxidant capacity of the oils. The melatonin carrier capacity and antioxidant performance was related to the degree of unsaturation of the oils and was highest for RO and WOO and lowest for LP. However, the most stable oil to oxidation was LP. The in vivo performance of the oils in the skin of eight healthy volunteers was investigated with a dermoanalyser. The highest increment of oil and hydration in the skin was obtained with RO. The lowest perception of oiliness was described for WOO, which produced the highest increase in elasticity of the skin area where it was applied. An in vitro-in vivo correlation was therefore performed through multivariable analysis (MVA).
eng
Attribution 4.0 International
In Vitro and In Vivo Characteristics of Olive Oil as Excipient for Topical Administration
journal article
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URL
https://docta.ucm.es/bitstreams/2915db05-2d48-472d-ab6b-a852d8e607a0/download
File
MD5
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application/pdf
Martapharmaceutics-14-02615.pdf
URL
https://docta.ucm.es/bitstreams/2d313d20-85b8-439b-b949-48ad9f076ea1/download
File
MD5
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text/plain
Martapharmaceutics-14-02615.pdf.txt