2026-06-27T23:19:48Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/993382025-03-18T12:51:39Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Solís García, Gonzalo author González Pacheco, Noelia author Ramos Navarro, Cristina author Vigil Vázquez, Sara author Gutiérrez Vélez, Ana author Merino Hernández, Amaia author Rodríguez Sánchez De la Blanca, Ana author Sánchez Luna, Manuel Ramón 2024-02-06T10:02:30Z 2024-02-06T10:02:30Z 2022-09-06 Solis‐Garcia G, González‐Pacheco N, Ramos‐Navarro C, et al. Lung recruitment inneonatal high‐frequency oscillatory ventilation with volume‐guarantee. Pediatric Pulmonology.2022;57:3000‐3008. doi:10.1002/ppul.26124 8755-68631099-0496 10.1002/ppul.26124 https://hdl.handle.net/20.500.14352/99338 https://onlinelibrary.wiley.com/doi/10.1002/ppul.26124 https://pubmed.ncbi.nlm.nih.gov/35996817/ Background and objectives: The optimal lung volume strategy during high-frequency oscillatory ventilation (HFOV) is reached by performing recruitment maneuvers, usually guided by the response in oxygenation. In animal models, secondary spontaneous change in oscillation pressure amplitude (ΔPhf) associated with a progressive increase in mean airway pressure during HFOV combined with volume guarantee (HFOV-VG) identifies optimal lung recruitment. The aim of this study was to describe recruitment maneuvers in HFOV-VG and analyze whether changes in ΔPhf might be an early predictor for lung recruitment in newborn infants with severe respiratory failure. Design and methods: The prospective observational study was done in a tertiary-level neonatology department. Changes in ΔPhf were analyzed during standardized lung recruitment after initiating early rescue HFOV-VG in preterm infants with severe respiratory failure. Results: Twenty-seven patients were included, with a median gestational age of 24 weeks (interquartile range [IQR]: 23-25). Recruitment maneuvers were performed, median baseline mean airway pressure (mPaw) was 11 cm H2 O (IQR: 10-13), median critical lung opening mPaw during recruitment was 14 cm H2 O (IRQ: 12-16), and median optimal mPaw was 12 cm H2 O (IQR: 10-14, p < 0.01). Recruitment maneuvers were associated with an improvement in oxygenation (FiO2 : 65.0 vs. 45.0, p < 0.01, SpO2/FiO2 ratio: 117 vs. 217, p < 0.01). ΔPhf decreased significantly after lung recruitment (mean amplitude: 23.0 vs. 16.0, p < 0.01). Conclusion: In preterm infants with severe respiratory failure, the lung recruitment process can be effectively guided by ΔPhf on HFOV-VG. eng Lung recruitment in neonatal high‐frequency oscillatory ventilation with volume‐guarantee journal article 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URL https://docta.ucm.es/bitstreams/9fa37255-ed4e-428c-b215-bafe8baf24cd/download File MD5 2f1047fe4e5210b2c9ef370c7f214ded 915748 application/pdf Lung recruitment in neonatal high-frequency oscillatory ventilation with volume-guarantee.22.pdf URL https://docta.ucm.es/bitstreams/954a65eb-93ed-4b2c-ae5f-e0b7dd28a9f1/download File MD5 861c86d2d149d0e25baf0e62670b5474 43098 text/plain Lung recruitment in neonatal high-frequency oscillatory ventilation with volume-guarantee.22.pdf.txt