2026-06-27T15:24:46Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/998682025-03-18T13:40:47Zcom_20.500.14352_14col_20.500.14352_15

Moreno Quispe, Luz A. Serrano Valle, Julia Virto Ruiz, Leire Sanz Alonso, Mariano Ramírez Sanz, Lucía Fernández Castro, Mónica Hernández Vallejo, Gonzalo López-Pintor Muñoz, Rosa María 2024-02-07T10:27:20Z 2024-02-07T10:27:20Z 2020-06-04 Moreno-Quispe LA, Serrano J, Virto L, et al. Association of salivary inflammatory biomarkers with primary Sjögren's syndrome. J Oral Pathol Med. 2020;00:1–8 0904-2512 10.1111/jop.13070 https://hdl.handle.net/20.500.14352/99868 1600-0714 https//doi.org/10.1111/jop.13070 32538490 https://onlinelibrary.wiley.com/doi/10.1111/jop.13070 Background: Primary Sjogren’s syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper-2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of IL-6, 5 and 4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient-reported outcomes (PROMs) for xerostomia and oral health quality of life (OHIP-14), pSS classification criteria and presence of extraglandular manifestations. Methods: A case-control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high-sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out the questionnaires. The U-Mann-Whitney test, chi-squared and Spearman correlation test were used. Results: IL-6 was significantly higher in pSS patients than in HCs (p=0.0001). IL-6 was significantly higher in pSS patients with a positive salivary gland biopsy (p=0.04), whole stimulated saliva hyposalivation (p=0.02) and presence of musculoskeletal disorders (p=0.03). There was a non-significant positive correlation between IL-6 levels and PROMs for xerostomia (r=0.31; p=0.06) and OHIP-14 (r=0.07; p=0.68) in pSS patients. Levels of IL4 and IL5 were not detected in both pSS and HCs patients. Conclusions: Salivary IL-6 levels were significantly associated with pSS patients and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow-up of this disease. eng open access Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome journal article