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Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over Caso Maestro, Óscar Jiménez Romero, Luis Carlos Justo Alonso, Iago Calvo Pulido, Jorge Lora Pablos, David Marcacuzco Quinto, Alberto Alejandro Cambra Molero, Félix García-Sesma Pérez-Fuentes, Álvaro Pérez Flecha, Marina Muñoz Arce, Carlos Loinaz Segurola, Carmelo Manrique Municio, Alejandro AIM To increase the number of available grafts. METHODS This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation (LT) were performed with donors ≥ 70 years old (study group). Then, we selected the first cases that were performed with donors < 70 years old immediately after the ones that were performed with donors ≥ 70 years old (control group). RESULTS Graft and patient survivals were similar between both groups without increasing the risk of complications, especially primary non-function, vascular complications and biliary complications. We identified 5 risk factors as independent predictors of graft survival: recipient hepatitis C virus (HCV)-positivity [hazard ratio (HR) = 2.35; 95% confidence interval (CI): 1.55-3.56; P = 0.00]; recipient age (HR = 1.04; 95%CI: 1.02-1.06; P = 0.00); donor age X model for end-stage liver disease (D-MELD) (HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); donor value of serum glutamic-pyruvic transaminase (HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); and donor value of serum sodium (HR = 0.96; 95%CI: 0.94-0.99; P = 0.00). After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD (donor age X recipient age X MELD). Graft survival significantly decreased in patients with a DR-MELD score ≥ 75000, especially in HCV patients (77% vs 63% at 5 years in HCV-negative patients, P = 0.00; and 61% vs 25% at 5 years in HCV-positive patients; P = 0.00). 2024-02-07T13:10:58Z 2024-02-07T13:10:58Z 2018-12-21 journal article Caso-Maestro O, Jiménez-Romero C, Justo-Alonso I, Calvo-Pulido J, Lora-Pablos D, Marcacuzco-Quinto A, Cambra-Molero F, García-Sesma A, Pérez-Flecha M, Muñoz-Arce C, Loinaz-Segurola C, Manrique-Municio A. Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over. World J Gastroenterol. 2018 Dec 21;24(47):5391-5402. doi: 10.3748/wjg.v24.i47.5391 1007-9327 10.3748/wjg.v24.i47.5391 https://hdl.handle.net/20.500.14352/99983 https://www.wjgnet.com/1007-9327/full/v24/i47/5391.htm https://pubmed.ncbi.nlm.nih.gov/30598583/ eng http://creativecommons.org/licenses/by-nc/4.0/ open access Attribution-NonCommercial 4.0 International https://pubmed.ncbi.nlm.nih.gov/30598583/