Reche Gallardo, Pedro AntonioSoumelis, VassiliGorman, D MClifford, TLiu, MRTravis, MZurawski, Sandra M.Johnston, JLiu, Yong-JunSpits, HWaal-Malefyt, Rene deKastelein, Robert A.Bazan, Fernando2023-06-202023-06-2020010022-176710.4049/​jimmunol.167.1.336https://hdl.handle.net/20.500.14352/58252The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R alpha-chain. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5. Human TSLPR and IL-7Ralpha are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent on various lymphoid cells. In accord, we find that human TSLP functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells, as evidenced by the strong induction of the costimulatory molecules CD40 and CD80 and the enhanced capacity to elicit proliferation of naive T cells.engjournal articlehttp://www.jimmunol.org/content/167/1/336.abstractopen access612.01757:004InmunologíaBiotecnologíaBiología molecular (Biología)2412 Inmunología3399 Otras Especialidades Tecnológicas2415 Biología Molecular