Beckers, Henny J.M.Aptel, FlorentWebers, Carroll A.B.Angeles, RaymundBluwol, ElisaMartínez De La Casa Fernández-Borrella, José MaríaGarcía Feijoo, JuliánLachkar, YvesMéndez Hernández, Carmen DoraRiss, IsabelleShao, HuiPinchuk, LeonardSadruddin, OmarShaarawy, Tarek M.2023-06-162023-06-162021-07-27Beckers, H. J. M., Aptel, F., Webers, C. A. B. et al. «Safety and Effectiveness of the PRESERFLO® MicroShunt in Primary Open-Angle Glaucoma». Ophthalmology Glaucoma, vol. 5, n.o 2, marzo de 2022, pp. 195-209. DOI.org (Crossref), https://doi.org/10.1016/j.ogla.2021.07.008.2589-419610.1016/j.ogla.2021.07.008https://hdl.handle.net/20.500.14352/4806To assess the safety and effectiveness of the PRESERFLO® MicroShunt (formerly InnFocus MicroShunt) in patients with primary open-angle glaucoma (POAG).The MicroShunt, a controlled ab externo glaucoma filtration surgery device, was investigated in a 2-year, multicenter, single-arm study.Eligible patients were aged 18-85 years with POAG inadequately controlled on maximal tolerated medical therapy with intraocular pressure (IOP) ≥18 and ≤35 mmHg or when glaucoma progression warranted surgery.The MicroShunt was implanted as a stand-alone procedure with adjunctive use of topical mitomycin C (MMC; 0.2-0.4 mg/ml) for 2-3 minutes.The primary effectiveness outcome was IOP reduction and success (not requiring reoperation or pressure failures [IOP > 21 mmHg and < 20% reduction in IOP]) at year 1. Additional end points at year 2 included IOP reduction, success, glaucoma medications, adverse events (AEs), and reoperations. Results are reported in the overall population and subgroups of patients receiving 0.2 or 0.4 mg/ml MMC.In 81 patients, mean (± standard deviation [SD]) IOP decreased from 21.7 ± 3.4 mmHg at baseline to 14.5 ± 4.6 mmHg at year 1 and 14.1 ± 3.2 mmHg at year 2 (P < 0.0001). Overall success (with and without supplemental glaucoma medication use) at year 1 was 74.1%. Mean (± SD) number of medications decreased from 2.1 ± 1.3 at baseline to 0.5 ± 0.9 at year 2 (P < 0.0001), and 73.8% of patients were medication free. Most common nonserious AEs were increased IOP requiring medication or selective laser trabeculoplasty (25.9%) and mild-to-moderate keratitis (11.1%). There were 6 (7.4%) reoperations and 5 (6.2%) needlings by year 2. In an analysis (post hoc) according to MMC concentration, overall success was 78.1% (0.2 mg/ml) and 74.4% (0.4 mg/ml; P = 0.710). In the 0.2 and 0.4 mg/ml MMC groups, 51.9% and 90.3% of patients were medication free, respectively (P = 0.001). There was a trend toward lower IOP and higher medication reduction in the 0.4 mg/ml MMC subgroup.In this study, mean IOP and glaucoma medication reductions were significant and sustained over 2 years postsurgery. No long-term, sight-threatening AEs were reported. Further studies may confirm potential risk/benefits of higher MMC concentrationengAtribución 3.0 Españajournal articlehttps://doi.org/10.1016/j.ogla.2021.07.008https://www.sciencedirect.com/science/article/pii/S2589419621001794?via%3Dihubopen access617.7‑007.681-089615.015.154612.842.6Clinical trialGlaucoma filtration surgeryMIGSPrimary open-angle glaucoma.CirugíaOftalmologíaÓptica oftálmica3213 Cirugía3201.09 Oftalmología