Cárdenas Escudero, J.Cáceres, Jorge OmarNavarro Villoslada, FernandoBellini, G.Galán Madruga, D.Cáceres, Jorge Omar2025-01-232025-01-232024J. Cardenas-Escudero, F. Navarro-Villoslada, G. Bellini, D. Galán-Madruga, J.O. Cáceres, Determination of bioequivalence between generic and reference drugs using laser-induced breakdown spectroscopy, Analytica Chimica Acta, Volume 1329, 2024, 343253, ISSN 0003-2670, https://doi.org/10.1016/j.aca.2024.343253.https://doi.org/10.1016/j.aca.2024.343253https://hdl.handle.net/20.500.14352/115750In vitro bioequivalence studies are strictly limited to the comparison of dissolution performance to a reference drug. These studies are performed without considering the chemical similarity between the generic and reference drug formulations. This work has focused on developing a groundbreaking method based on the laser-induced breakdown spectroscopy (LIBS) technique for the in vitro bioequivalence determination of immediate-release solid oral dosage form generic drugs and as an alternative method for establishing the biowaiver of in vivo generic drug studies.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1016/j.aca.2024.343253https://www.sciencedirect.com/science/article/pii/S0003267024010547open access543Laser-induced breakdown spectroscopyGeneric drugIn-vitro bioequivalenceBiopharmaceutical classification systemCiencias23 Química