Calmarza-Font, IsabelLagunas García, Luisa NataliaGarcia-Segura, Luis2024-01-252024-01-252012Calmarza-Font I, Lagunas N, Garcia-Segura LM. Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress. Behav Brain Res. 2012 Feb 1;227(1):287-90. doi: 10.1016/j.bbr.2011.10.036. Epub 2011 Oct 29. PMID: 22061801.0166-432810.1016/j.bbr.2011.10.036https://hdl.handle.net/20.500.14352/95507Estradiol has antidepressive and anxiolytic actions. However, its therapeutic use is limited by its peripheral effects. Selective estrogen receptor modulators may represent an alternative to estradiol for the treatment of depressive symptoms. Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://www.doi.org/10.1016/j.bbr.2011.10.036https://www.sciencedirect.com/science/article/pii/S0166432811007698?via%3Dihubrestricted access611.81Elevated plus mazeEstradiolForced swim testRaloxifeneTamoxifenPsicología fisiológica2490 Neurociencias