Ruiz Serrano, MiriamLópez-Alvarado Gutiérrez, María PilarMenéndez Ramos, José Carlos2025-12-152025-12-152010Ruiz M, López-Alvarado P, Menéndez JC. Concise and very efficient synthesis of the N-methylwelwistatin tetracyclic core based on an anionic domino process. Org Biomol Chem. 2010 Oct 21;8(20):4521-3. doi: 10.1039/c0ob00382d. Epub 2010 Aug 18. PMID: 20717611.1477-052010.1039/c0ob00382dhttps://hdl.handle.net/20.500.14352/128965Received 5th July 2010, Accepted 3rd August 2010An efficient synthesis of the N-methylwelwistatin tetracyclic core in only two steps from Kornfeld's ketone is described, whose key transformation involves the generation of a fused bicyclo[4.3.1]decane ring system through a one-pot sequence comprising a Michael-intramolecular aldolization anionic domino process and a DBU-promoted hydrolysis of the N-pivaloyl protecting group. Besides providing the most efficient synthesis of the welwistatin core to date, this method has the advantage of installing an oxygenated function at the welwistatin D ring.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1477-0539https://doi.org/10.1039/C0OB00382Dhttps://pubs.rsc.org/en/content/articlelanding/2010/ob/c0ob00382d#!divAbstracthttps://pubs.rsc.org/en/content/articlepdf/2010/ob/c0ob00382dopen access615:54615.31661.185N-methylwelwistatinDomino processSynthesisQuímica farmaceúticaQuímica orgánica (Farmacia)2306.90 Química de Productos Naturales Orgánicos2306 Química Orgánica