Lucientes Continente, LauraMárquez Tirado, BárbaraGoicoechea de Jorge, Elena2023-06-222023-06-222022-11-160105-289610.1111/imr.13166https://hdl.handle.net/20.500.14352/72698CRUE-CSIC (Acuerdos Transformativos 2022)The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including infectious, inflammatory, autoimmune, and degenerative diseases and cancer. Composed, in man, of seven highly related proteins, FH, factor H-like 1, and 5 factor H-related proteins, some of the FH family proteins are devoted to down-regulating the AP, while others exert an opposite function by promoting AP activation. Recent findings have provided insights into the molecular mechanisms defining their biological roles and their pathogenicity, illustrating the relevance that the balance between the regulators and the activators within this protein family has in defining the outcome of complement activation on cell surfaces. In this review we will discuss the emerging roles of the factor H protein family, their impact in the complement cascade, and their involvement in the pathogenesis of complementmediated diseases associated with the AP dysregulation.engAtribución-NoComercial-SinDerivadas 3.0 Españajournal articlehttps://doi.org/10.1111/imr.13166open accessalternative pathwaycomplementFactor HFHL-1FHRsInmunología2412 Inmunología