Ramos Soriano, JavierReina, José J.Illescas, Beatriz M.Rojo, JavierMartín, Nazario2023-06-172023-06-172018-01-090022-3263 (Print)1520-6904 (Online)10.1021/acs.joc.7b02402https://hdl.handle.net/20.500.14352/11975The synthesis of multivalent systems based on hexakisadducts of [60]fullerene employing a biocompatible copper-free click chemistry strategy has been accomplished. A symmetric hexakis-adduct of fullerene bearing 12 maleimide units (3) is reported, and it has been employed to carry out the thiol-maleimide Michael addition. To achieve orthogonal click addition, an asymmetric derivative bearing one maleimide and 10 cyclooctynes has been synthesized. The sequential and one-pot transformations of the two clickable groups have been explored, finding the best results in the case of the one-pot experiment. This route has been used to obtain a biocompatible hexakis-adduct appended with two different biomolecules, carbohydrates, and amino acids.engjournal articlehttps://pubs.acs.org/doi/pdf/10.1021/acs.joc.7b02402open access547Química orgánica (Química)2306 Química Orgánica