Jiménez Pérez, EvaVázquez, AlbertoGonzález Soto, SaraSacedón Ayuso, RosaMartínez Fernández De Sevilla, LidiaVaras Fajardo, AlbertoSubiza Garrido-Lestache, José LuisValencia Mahón, JarisVicente López, María Ángeles2025-01-162025-01-162024-12-20Jiménez, E.; Vázquez, A.; González, S.; Sacedón, R.; Fernández-Sevilla, L.M.; Varas, A.; Subiza, J.L.; Valencia, J.; Vicente, Á. Mucosal Bacterial Immunotherapy Attenuates the Development of Experimental Colitis by Reducing Inflammation Through the Regulation of Myeloid Cells. Int. J. Mol. Sci. 2024, 25, 13629.1422-006710.3390/ijms252413629https://hdl.handle.net/20.500.14352/114658Fondos FEDERUlcerative colitis is a chronic relapsing–remitting and potentially progressive form of inflammatory bowel disease in which there is extensive inflammation and mucosal damage in the colon and rectum as a result of an abnormal immune response. MV130 is a mucosal-trained immunity-based vaccine used to prevent respiratory tract infections in various clinical settings. Additionally, MV130 may induce innate immune cells that acquire anti-inflammatory properties and promote tolerance, which could have important implications for chronic inflammatory diseases such as ulcerative colitis. This work demonstrated that the prophylactic administration of MV130 substantially mitigated colitis in a mouse model of acute colitis induced by dextran sulphate sodium. MV130 downregulated systemic and local inflammatory responses, maintained the integrity of the intestinal barrier by preserving the enterocyte layer and goblet cells, and reduced the oedema and fibrosis characteristic of the disease. Mechanistically, MV130 significantly reduced the infiltration of neutrophils and pro-inflammatory macrophages in the intestinal wall of the diseased animals and favoured the appearance of M2-polarised macrophages. These results suggest that MV130 might have therapeutic potential for the treatment of ulcerative colitis, reducing the risk of relapse and the progression of disease.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1661-6596https://doi.org/10.3390/ ijms25241362939769391https://www.mdpi.com/1422-0067/25/24/13629https://pubmed.ncbi.nlm.nih.gov/39769391/open access576612.017Ulcerative colitisInflammationBacterial immunotherapyVaccine MV130ImmunomodulationMacrophagesNeutrophilsInmunologíaGastroenterología y hepatologíaBiología celular (Biología)Medicina2407 Biología Celular3201.04 Patología Clínica