Clemente-Suárez, Vicente JavierRey-Mota, JorgeEscribano-Colmena, GuillermoMarín, Noelia VanessaFernández Lucas, Jesús2025-08-082025-08-082025-07-27Clemente-Suárez, V. J., Rey-Mota, J., Escribano-Colmena, G., Marín, N. V., & Fernandez-Lucas, J. (2025). The effect of a single functional neurology session on thermography of the genital region and sexual function in patients with premature ejaculation. Sexual Medicine, 13(3), qfaf046. https://doi.org/10.1093/sexmed/qfaf0462050-116110.1093/sexmed/qfaf046https://hdl.handle.net/20.500.14352/123150Funding: None declared. Acknowledgments: The authors thank the volunteers for their participation. We also acknowledge the technical support and assistance of the research staff involved in thermography analysis. No editorial assistance was used in the preparation of this manuscript. Conflicts of interest: None declared.Background Premature ejaculation (PE) is a common male sexual dysfunction with limited long-term therapeutic options. Pharmacological and behavioral treatments often yield only temporary improvement, and alternative neuromodulatory strategies remain underexplored. Functional neurology, which targets autonomic and sensory-motor regulation, may offer a novel approach. Aim To evaluate the effect of a single functional neurology intervention on genital thermoregulation and ejaculatory latency in men with PE. Methods Fifty-two men diagnosed with PE participated in a pre–post intervention study. Each underwent a single session of functional neurology aimed at modulating nociceptor and mechanoreceptor pathways. Genital thermoregulation was assessed using infrared thermography, and ejaculatory function was measured via intravaginal ejaculatory latency time (IELT) and self-report at baseline, after the first post-treatment sexual encounter, and at 1-month follow-up. Statistical analyses included repeated-measures ANOVA, paired t-tests, Pearson correlation, and multiple regression. Outcomes Significant improvements in IELT and genital temperature were expected following the intervention, supporting its role in enhancing autonomic regulation and microvascular circulation. Results Intravaginal ejaculatory latency time increased significantly from a baseline of 20.4 ± 11.5 seconds to 439.2 ± 214.5 seconds post-treatment, with sustained effects at 1 month (498.0 ± 171.6 seconds; P < .001). Infrared thermography revealed significant increases in temperature in the glans, testicles, and abdomen (all P < .001), indicating enhanced peripheral circulation. Glans temperature change was the strongest predictor of testicular thermoregulation (β = 0.513, P < .001). Principal component analysis highlighted that glans and testicular areas contributed most to thermal variance post-treatment. A ≥1 °C increase in genital temperature was observed in 60% of participants. Clinical Implications Functional neurology may be a non-invasive, fast-acting intervention for improving ejaculatory control in PE by promoting autonomic balance and vascular function. Thermography proved useful as a biomarker for physiological changes and treatment efficacy. Strengths and Limitations This study is the first to evaluate thermographic and ejaculatory outcomes after a functional neurology intervention in PE. Strengths include objective and subjective measures, while limitations involve the lack of a control group, small sample size, and short-term follow-up. These results should be confirmed through randomized controlled trials. Conclusion A single session of functional neurology significantly improved both genital thermoregulation and ejaculatory latency in men with PE. These findings support the integration of neuromodulatory techniques into multidisciplinary strategies for sexual dysfunction treatment.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal articlehttps://doi.org/10.1093/sexmed/qfaf046open access612.669.7612.82613.956Premature ejaculationEjaculationIntravaginal ejaculatory latency timeFunctional neurologyAutonomic nervous systemThermographyGenital blood flowVascular regulationBioquímica (Biología)Neurociencias (Biológicas)Medio ambiente naturalSalud pública (Medicina)2414 Microbiología2415 Biología Molecular2411 Fisiología Humana2490 Neurociencias3205 Medicina Interna