Suárez González, Luz MaríaDíaz Del Cerro, EstefaníaFélix, JudithGonzález Sánchez, MónicaCeprián, NoemíGuerra Pérez, NataliaGarrido Novelle, MartaMartínez De Toda Cabeza, IreneFuente Del Rey, María Mónica De La2023-11-032023-11-032023Suarez LM, Diaz-Del Cerro E, Felix J, Gonzalez-Sanchez M, Ceprian N, Guerra-Perez N, Novelle MG, Martinez de Toda I, De la Fuente M. Sex differences in neuroimmunoendocrine communication. Involvement on longevity. Mech Ageing Dev. 2023 Apr;211:111798.0047-637410.1016/j.mad.2023.111798https://hdl.handle.net/20.500.14352/88568Endocrine, nervous, and immune systems work coordinately to maintain the global homeostasis of the organism. They show sex differences in their functions that, in turn, contribute to sex differences beyond reproductive function. Females display a better control of the energetic metabolism and improved neuroprotection and have more antioxidant defenses and a better inflammatory status than males, which is associated with a more robust immune response than that of males. These differences are present from the early stages of life, being more relevant in adulthood and influencing the aging trajectory in each sex and may contribute to the different life lifespan between sexes.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1016/j.mad.2023.111798open access612.67AgingGonadal hormonesImmune systemNervous systemEnergetic metabolismFisiología2410.10 Fisiología Humana2402.15 Envejecimiento Somático