Almendros Requena, PedroYanai, HikaruHoshikawa, ShokiAragoncillo Abanades, CristinaLázaro Milla, CarlosToledano-Pinedo, MireiaMatsumoto, TakashiAlcaide Alañón, Benito2024-01-092024-01-092018Almendros P, Yanai H, Hoshikawa S, Aragoncillo C, Lázaro-Milla C, Toledano-Pinedo M, Matsumoto T, Alcaide B. Transition Metal-Free Controlled Synthesis of Bis[(Trifluoromethyl)Sulfonyl] Ethyl-Decorated Heterocycles. Org. Chem. Front. 2018, 5, 3163-3169.2052-412910.1039/c8qo00955dhttps://hdl.handle.net/20.500.14352/91958Several heterocycles reacted with shelf-stable 2-(2-fluoropyridinium-1-yl)-1,1-bis[(trifluoromethyl)sulfonyl] ethan-1-ide, a latent Tf2CvCH2 source, to give rise in a mild and controllable way to adducts via direct C–H bis[(trifluoromethyl)sulfonyl]ethylation reactions. This metal- and irradiation-free protocol is convenient. Besides, the volatile side-product 2 fluoropyridine can be smoothly eliminated under vacuum, which facilitates purification. The substrate scope survey discloses that exquisite chemo- and regioselectivities are achieved in a variety of heterocyclic systems. Of particular interest are the late-stage structural modification of known pharmaceuticals, such as the marketed drugs Phenazone (Antipyrine) and Edaravone, and the development of a water soluble fluorescent dye.engjournal articlehttps://doi.org/10.1039/c8qo00955dmetadata only access547HeterocyclesTriflyl groupCienciasQuímica orgánica (Química)2306.10 Compuestos Heterocíclicos