Sánchez-Archidona, Ana R.Jiménez Martínez, María De Los ÁngelesPérez Alenza, María De Los DoloresSilván Granado, GemaIllera Del Portal, Juan CarlosPeña Fernández, Laura LuisaDunner Boxberger, Helene Susana2024-01-302024-01-302007Sánchez-Archidona, Ana R., et al. «Steroid pathway and oestrone sulphate production in canine inflammatory mammary carcinoma». The Journal of Steroid Biochemistry and Molecular Biology, vol. 104, n.o 3, mayo de 2007, pp. 93-99. ScienceDirect, https://doi.org/10.1016/j.jsbmb.2007.03.014.0960-076010.1016/j.jsbmb.2007.03.014https://hdl.handle.net/20.500.14352/96321Spontaneous canine mammary inflammatory carcinoma (IMC) shares epidemiologic, histopathologic and clinical characteristics with the inflammatory breast carcinoma (IBC) disease in humans. We have analysed the steroids levels in serum and in tissue homogenates of IMC, the expression of two of their receptors (androgen and β-estrogen) and of three enzymes included in the steroidogenesis pathway (aromatase (CYP19A1), steroid sulphatase (STS) and estrogen sulfotransferase (EST)) trying to explain the specific accumulation of steroids in IMC tissues generating deposits in the form of lipid droplets whose presence can be attributed to steroids secreted by IMC cells. According to our working hypothesis, oestrone sulphate would be the main component of these lipid droplets. The presence of these steroid deposits would contribute to the intense proliferation and invasive behaviour of IMC and IBC, although their involvement in angiogenesis is yet to be demonstrated.engAttribution-NonCommercial-NoDerivatives 4.0 Internationaljournal articlehttps://doi.org/10.1016/j.jsbmb.2007.03.01417466517restricted access61Steroid hormonesSteroid receptorsOestrone sulphate pathwayCanine inflammatory mammary carcinomaCiencias Biomédicas32 Ciencias Médicas