Utrero Rico, AlbertoLaguna Goya, RocíoCano Romero, Francisco LuisChivite Lacaba, MartaGonzález Cuadrado, CeciliaRodríguez Sánchez, ElenaRuíz Hurtado, GemaSerrano, AntonioFernández Ruiz, MarioJusto Alonso, IagoGonzález Monte, EstherAndrés Belmonte, AmadoPaz Artal, Estela Natividad2025-01-282025-01-282020-12Utrero-Rico, Alberto MSc1; Laguna-Goya, Rocio MD, PhD1,2; Cano-Romero, Francisco MSc1; Chivite-Lacaba, Marta BSc1; Gonzalez-Cuadrado, Cecilia MSc1; Rodríguez-Sánchez, Elena MSc4; Ruiz-Hurtado, Gema PhD4,5; Serrano, Antonio MD, PhD1,2; Fernández-Ruiz, Mario MD, PhD1,6; Justo, Iago MD, PhD7; González, Esther MD, PhD8; Andrés, Amado MD, PhD8; Paz-Artal, Estela MD, PhD1,2,3. Early Posttransplant Mobilization of Monocytic Myeloid-derived Suppressor Cell Correlates With Increase in Soluble Immunosuppressive Factors and Predicts Cancer in Kidney Recipients. Transplantation 104(12):p 2599-2608, December 2020. | DOI: 10.1097/TP.00000000000031790041-133710.1097/TP.0000000000003179https://hdl.handle.net/20.500.14352/116470Background: Myeloid-derived suppressor cells (MDSCs) increase in patients with cancer and are associated with poor prognosis; however, their role in transplantation is not yet understood. Here we aimed to study the MDSC effects on the evolution of kidney transplant recipients (KTRs). Methods: A cohort of 229 KTRs was prospectively analyzed. Two myeloid cells subsets. CD11bCD33CD14CD15HLA-DR (monocytic MDSC [M-MDSC]) and CD11bCD33CD14CD15HLA-DR (monocytes), were defined by flow cytometry. The suppressive capacity of myeloid cells was tested in cocultures with autologous lymphocytes. Suppressive soluble factors, cytokines, anti-HLA antibodies, and total antioxidant capacity were quantified in plasma. Results: Pretransplant, M-MDSC, and monocytes were similar in KTRs and healthy volunteers. M-MDSCs increased immediately posttransplantation and suppressed CD4 and CD8 T cells proliferation. M-MDSCs remained high for 1 y posttransplantation. Higher M-MDSC counts at day 14 posttransplant were observed in patients who subsequently developed cancer, and KTRs with higher M-MDSC at day 14 had significantly lower malignancy-free survival. Day 14 M-MDSC >179.2 per microliter conferred 6.98 times (95% confidence interval, 1.28-37.69) more risk to develop cancer, independently from age, gender, and immunosuppression. Early posttransplant M-MDSCs were lower in patients with enhanced alloimmune response as represented by anti-HLA sensitization. M-MDSC counts correlated with higher circulatory suppressive factors arginase-1 and interleukin-10, and lower total antioxidant capacity. Conclusions: Early posttransplant mobilization of M-MDSCs predicts cancer and adds risk as an independent factor. M-MDSC may favor an immunosuppressive environment that promotes tumoral development.engjournal article1534-6080https://doi.org/10.1097/TP.0000000000003179https://journals.lww.com/transplantjournal/fulltext/2020/12000/early_posttransplant_mobilization_of_monocytic.26.aspxrestricted access612.017trasplante renalcélulas mieloides supresorascáncerCiencias Biomédicas2412 Inmunología