Cafini, FabioAlou Cervera, LuisSevillano Fernández, DavidValero, EvaPrieto Prieto, José2024-07-292024-07-292004-10Cafini F, Alou L, Sevillano D, Valero E, Prieto J; Spanish Pneumococcal Infection Study Network (G03/103). Bactericidal activity of moxifloxacin against multidrug-resistant Streptoccocus pneumoniae at clinically achievable serum and epithelial lining fluid concentrations compared with three other antimicrobials. Int J Antimicrob Agents. 2004 Oct;24(4):334-8.0924-857910.1016/j.ijantimicag.2004.04.015https://hdl.handle.net/20.500.14352/107187Time-kill studies compared the activities of moxifloxacin with those of levofloxacin, azithromycin and amoxicillin-clavulanate against 10 pneumococcal strains with various drug susceptibilities. Three Streptococcus pneumoniae strains were resistant to moxifloxacin: 6, 7 and 2 strains were resistant to levofloxacin, azithromycin and amoxicillin-clavulanate, respectively. Of these, 1 strain was resistant to all antimicrobial agents studied. Moxifloxacin and amoxicillin-clavulanate were bactericidal after 24h at serum Cmax levels against 9 and 8 strains, respectively, while levofloxacin and azithromycin were bactericidal against 3 and 2 strains, respectively. A higher activity was only observed for amoxicillin-clavulanate for logarithmic phase cultures at 1, 4 and 8h compared with stationary phase organisms. Amoxicillin-clavulanate and moxifloxacin were bactericidal at free serum levels (protein unbound) after 24h against 8 and 3 strains, respectively. Moxifloxacin was bactericidal at epithelial lining fluid levels against all strains at 24h, including one moxifloxacin, amoxicillin-clavulanate and azithromycin-resistant strain; lower levels of bactericidal activity was observed for levofloxacin, azithromycin and amoxicillin-clavulanate against 7, 2 and 4 strains, respectively. This demonstrated the importance of moxifloxacin tissue levels.engjournal articlehttps://doi.org/10.1016/j.ijantimicag.2004.04.015https://www.sciencedirect.com/science/article/pii/S0924857904002158restricted access611.02SerumEpithelial lining fluidBactericidalStationaryLogarithmicMicrobiología médica2414 Microbiología