Alonso Monge, Rebeca María Del MarIsabel Cortés-PrietoRomán González, ElviraPla Alonso, Jesús2025-12-182025-12-182024Rebeca Alonso-Monge, Isabel Cortés-Prieto, Elvira Román, Jesús Pla, Morphogenetic transitions in the adaptation of Candida albicans to the mammalian gut, Microbes and Infection, Volume 26, Issue 3, 2024, 105253, ISSN 1286-4579, https://doi.org/10.1016/j.micinf.2023.10525310.1016/j.micinf.2023.105253https://hdl.handle.net/20.500.14352/129351Candida albicans is a pathobiont in humans that forms part of the mycobiota in healthy individuals and can cause different pathologies upon alterations of the host defenses. The mammalian gut is clinically relevant as this niche is the most common pool for bloodstream-derived infections. The ability of C. albicans to switch from yeast to hypha has been related to the commensal-to-pathogen transition and is, therefore, considered relevant in virulence. Recently, filaments have been implicated in the humoral response in the gut. C. albicans exhibits other morphologies that play different roles in pathogenicity and commensalism. This review focuses on the role of these morphological transitions in C. albicans proliferation and its establishment as a commensal in the mammalian gut, paying special attention to the transcription factors involved in their regulation.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/review articlehttps://doi.org/10.1016/j.micinf.2023.105253open access579CommensalismDimorphismWhite opaque transitionCandida albicansMicrobiología (Farmacia)2414 Microbiología2415.01 Biología Molecular de Microorganismos