Stereochemical issues related to the synthesis and reactivity of pyrazino[20 ,10 -5,1]pyrrolo[2,3-b]indole-1,4-diones

Caballero, EsmeraldaAvendaño López, María CarmenMenéndez, J. Carlos2026-02-262026-02-261998Caballero E, Avendaño C, Menéndez JC. Stereochemical issues related to the synthesis and reactivity of pyrazino[2′,1′-5,1]pyrrolo[2,3-b]indole-1,4-diones. Tetrahedron: Asymmetry. marzo de 1998;9(6):967-81. doi:10.1016/S0957-4166(98)00068-810.1016/S0957-4166(98)00068-8https://hdl.handle.net/20.500.14352/133371The cyclization of all four diastereoisomers of cyclo-(Trp-Ala) to the corresponding 3,5a,6,10b,11,11ahexahydro-2H-pyrazino[20 ,10 -5,1]pyrrolo[2,3-b]indoles is studied from the stereochemical point of view. Epimerization of the tryptophan stereocenter during the cyclization and during acylation reactions of the N-2 atom of the tetracyclic derivatives is discussed.engStereochemical issues related to the synthesis and reactivity of pyrazino[20 ,10 -5,1]pyrrolo[2,3-b]indole-1,4-dionesjournal articlehttps://dx.doi.org/10.1016/S0957-4166(98)00068-8restricted access547Química orgánica (Farmacia)2306 Química Orgánica